P21

CDKN1A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1AXC, 2ZVV, 2ZVW, 4RJF, 5E0U

Identifiers

Aliases

CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A

External IDs

OMIM: 116899 MGI: 104556 HomoloGene: 333 GeneCards: CDKN1A

Gene ontology
Molecular function	• protein complex binding • protein kinase inhibitor activity • metal ion binding • protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • ubiquitin protein ligase binding • cyclin binding • cyclin-dependent protein kinase activating kinase activity
Cellular component	• cytoplasm • cytosol • cyclin-dependent protein kinase holoenzyme complex • PCNA-p21 complex • perinuclear region of cytoplasm • nucleus • nucleoplasm • nucleolus • nuclear body • protein complex
Biological process	• cellular response to extracellular stimulus • signal transduction by p53 class mediator • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • mitotic cell cycle arrest • cellular response to heat • regulation of cyclin-dependent protein serine/threonine kinase activity • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of cell death • response to organic cyclic compound • negative regulation of cyclin-dependent protein serine/threonine kinase activity • stress-induced premature senescence • positive regulation of fibroblast proliferation • replicative senescence • response to hyperoxia • G1/S transition of mitotic cell cycle • response to corticosterone • cellular response to amino acid starvation • positive regulation of programmed cell death • negative regulation of apoptotic process • response to glucocorticoid • response to arsenic-containing substance • regulation of DNA biosynthetic process • regulation of protein import into nucleus, translocation • response to organic substance • negative regulation of gene expression • cellular response to DNA damage stimulus • negative regulation of G1/S transition of mitotic cell cycle • regulation of cell cycle • intrinsic apoptotic signaling pathway • cellular senescence • positive regulation of reactive oxygen species metabolic process • cellular response to UV-B • G2/M transition of mitotic cell cycle • positive regulation of B cell proliferation • negative regulation of cell growth • cell cycle arrest • response to organonitrogen compound • animal organ regeneration • regulation of mitotic cell cycle • intestinal epithelial cell maturation • cellular response to ionizing radiation • cell cycle • Ras protein signal transduction • negative regulation of phosphorylation • response to toxic substance • response to UV • response to X-ray • response to drug • negative regulation of cell proliferation • protein stabilization • positive regulation of cyclin-dependent protein kinase activity • regulation of transcription from RNA polymerase II promoter • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of protein kinase activity • cellular response to gamma radiation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1026


12575

Ensembl


ENSG00000124762


ENSMUSG00000023067

UniProt


P38936


P39689

RefSeq (mRNA)


NM_078467 NM_000389 NM_001220777 NM_001220778 NM_001291549


NM_001111099 NM_007669

RefSeq (protein)


NP_000380 NP_001207706 NP_001207707 NP_001278478 NP_510867


NP_001104569.1 NP_031695.1 NP_001104569 NP_031695

Location (UCSC)

Chr 6: 36.68 – 36.69 Mb

Chr 17: 29.09 – 29.1 Mb

PubMed search

1AXC, 2ZVV, 2ZVW, 4RJF, 5E0U

NM_078467
NM_000389
NM_001220777
NM_001220778
NM_001291549

NM_001111099
NM_007669

NP_000380
NP_001207706
NP_001207707
NP_001278478
NP_510867

...
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