P110 alpha

PIK3CA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ENQ, 2RD0, 3HHM, 3HIZ, 3ZIM, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4TUU, 4TV3, 4WAF, 4YKN, 5DXH, 5DXT, 5FI4, 4ZOP
Identifiers
Aliases	PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha, PI3K-alpha, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
External IDs	OMIM: 171834 MGI: 1206581 HomoloGene: 21249 GeneCards: PIK3CA
EC number	2.7.11.1
Gene location (Human) Chr. Chromosome 3 (human) Band 3q26.32 Start 179,148,114 bp End 179,240,093 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 A3|3 15.7 cM Start 32,397,671 bp End 32,468,486 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activator activity • 1-phosphatidylinositol-4-phosphate 3-kinase activity • protein serine/threonine kinase activity • protein binding • phosphatidylinositol 3-kinase activity • insulin receptor substrate binding • ATP binding • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • kinase activity Cellular component • phosphatidylinositol 3-kinase complex • cytosol • phosphatidylinositol 3-kinase complex, class IA • plasma membrane • lamellipodium • cytoplasm Biological process • negative regulation of neuron apoptotic process • cardiac muscle contraction • epidermal growth factor receptor signaling pathway • protein kinase B signaling • Fc-gamma receptor signaling pathway involved in phagocytosis • regulation of multicellular organism growth • T cell costimulation • hypomethylation of CpG island • positive regulation of peptidyl-serine phosphorylation • platelet activation • Fc-epsilon receptor signaling pathway • phosphatidylinositol phosphorylation • vascular endothelial growth factor receptor signaling pathway • vasculature development • angiogenesis • insulin receptor signaling pathway via phosphatidylinositol 3-kinase • glucose metabolic process • phagocytosis • energy homeostasis • phosphatidylinositol biosynthetic process • negative regulation of fibroblast apoptotic process • regulation of gene expression • liver development • adipose tissue development • regulation of cellular respiration • T cell receptor signaling pathway • activation of protein kinase activity • regulation of genetic imprinting • negative regulation of anoikis • cellular response to glucose stimulus • endothelial cell migration • phosphatidylinositol-mediated signaling • leukocyte migration • ERBB2 signaling pathway • phosphatidylinositol-3-phosphate biosynthetic process • axon guidance • negative regulation of macroautophagy • phosphorylation • positive regulation of TOR signaling • anoikis • adaptive immune response • protein phosphorylation • inflammatory response • phosphatidylinositol 3-kinase signaling • innate immune response • cell chemotaxis • interleukin-7-mediated signaling pathway • G-protein coupled receptor signaling pathway • positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5290	18706
Ensembl	ENSG00000121879	ENSMUSG00000027665
UniProt	P42336	P42337
RefSeq (mRNA)	NM_006218	NM_008839
RefSeq (protein)	NP_006209	NP_032865
Location (UCSC)	Chr 3: 179.15 – 179.24 Mb	Chr 3: 32.4 – 32.47 Mb
PubMed search

2ENQ, 2RD0, 3HHM, 3HIZ, 3ZIM, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4TUU, 4TV3, 4WAF, 4YKN, 5DXH, 5DXT, 5FI4, 4ZOP

5290

18706

ENSG00000121879

ENSMUSG00000027665

P42336

...
Wikipedia