P0 protein

Myelin-PO_C
Identifiers
Symbol	Myelin-PO_C
Pfam	PF10570
InterPro	IPR019566
OPM superfamily	230
OPM protein	3oai
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

MPZ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OAI
Identifiers
Aliases	MPZ, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0, myelin protein zero
External IDs	OMIM: 159440 MGI: 103177 HomoloGene: 445 GeneCards: MPZ
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.3 Start 161,304,735 bp End 161,309,972 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H3|1 79.05 cM Start 171,150,711 bp End 171,161,130 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity Cellular component • integral component of membrane • myelin • rough endoplasmic reticulum • lysosome • basolateral plasma membrane • integral component of plasma membrane • membrane • plasma membrane Biological process • negative regulation of apoptotic process • chemical synaptic transmission • myelination • cell-cell adhesion via plasma-membrane adhesion molecules • cell aggregation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4359	17528
Ensembl	ENSG00000158887	ENSMUSG00000056569
UniProt	P25189	P27573
RefSeq (mRNA)	NM_000530 NM_001315491	NM_008623 NM_001315499 NM_001315500
RefSeq (protein)	NP_000521 NP_001302420	NP_001302428 NP_001302429 NP_032649
Location (UCSC)	Chr 1: 161.3 – 161.31 Mb	Chr 1: 171.15 – 171.16 Mb
PubMed search

3OAI

4359

17528

ENSG00000158887

ENSMUSG00000056569

P25189

P27573

NM_000530
NM_001315491

NM_008623
NM_001315499
NM_001315500

NP_000521
NP_001302420

NP_001302428
NP_001302429
NP_032649

Myelin protein zero (P0, MPZ) is a glycoprotein which in humans is encoded by the MPZ gene. P0 is a major structural component of the myelin sheath, and its deficiency due to various mutations in the MPZ gene is associated with Charcot–Marie–Tooth disease and Dejerine–Sottas disease.

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Wikipedia