P-glycoprotein

ABCB1
Identifiers
Aliases	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1
External IDs	MGI: 97570 HomoloGene: 55496 GeneCards: ABCB1
Gene ontology Molecular function • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • transporter activity • ATPase activity • protein binding • hydrolase activity • ATP binding • xenobiotic-transporting ATPase activity • phosphatidylethanolamine-translocating ATPase activity • phosphatidylcholine-translocating ATPase activity • ceramide-translocating ATPase activity Cellular component • integral component of membrane • membrane • plasma membrane • cell surface • extracellular exosome • apical plasma membrane Biological process • stem cell proliferation • xenobiotic transport • G2/M transition of mitotic cell cycle • transmembrane transport • transport • response to drug • phospholipid translocation • drug transmembrane transport • ceramide translocation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5243	18671
Ensembl	ENSG00000085563	ENSMUSG00000040584
UniProt	P08183	P21447
RefSeq (mRNA)	NM_000927	NM_011076
RefSeq (protein)	NP_000918	NP_035206.2 NP_035206
Location (UCSC)	Chr 7: 87.5 – 87.71 Mb	Chr 5: 8.66 – 8.75 Mb
PubMed search

ABCB1 at EBI Gene Expression Atlas
ABCB1 is differentially expressed in 97 experiments [93 up/106 dn]: 26 organism parts: kidney [2 up/0 dn], bone marrow [0 up/2 dn], ...; 29 disease states: normal [10 up/3 dn], glioblastoma [0 up/2 dn], ...; 30 cell types, 22 cell lines, 11 compound treatments and 16 other conditions.
Factor Value	Factor	Up/Down
Legend: - number of studies the gene is up/down in
Normal	Disease state	10/3
None	Compound treatment	3/0
Stromal cell	Cell type	1/2
Kidney	Cell type	2/0
MDA-MB-231	Cell line	0/2
Glioblastoma	Disease state	0/2
Epithelial cell	Cell type	0/2
HeLa	Cell line	0/2
Primary	Disease staging	2/0
Bone marrow	Organism part	0/2
ABCB1 expression data in ATLAS

5243

18671

ENSG00000085563

ENSMUSG00000040584

P08183

P21447

NM_000927

NM_011076

NP_000918

NP_035206.2
NP_035206

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances.

P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in where it pumps them into bile ducts, in the cells of the proximal tubule of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells composing the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries.

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Wikipedia