P-cadherin

CDH3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OY9
Identifiers
Aliases	CDH3, CDHP, HJMD, PCAD, cadherin 3
External IDs	MGI: 88356 HomoloGene: 20425 GeneCards: CDH3
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 68,636,189 bp End 68,722,616 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 D3|8 53.16 cM Start 106,510,891 bp End 106,557,297 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • metal ion binding • molecular function Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • cell-cell adherens junction Biological process • hair cycle process • positive regulation of keratinocyte proliferation • negative regulation of timing of catagen • response to stimulus • keratinization • wound healing • regulation of hair cycle by canonical Wnt signaling pathway • negative regulation of transforming growth factor beta2 production • positive regulation of monophenol monooxygenase activity • retina homeostasis • positive regulation of gene expression • cell adhesion • positive regulation of insulin-like growth factor receptor signaling pathway • canonical Wnt signaling pathway • positive regulation of melanin biosynthetic process • positive regulation of melanosome transport • adherens junction organization • response to drug • visual perception • homophilic cell adhesion via plasma membrane adhesion molecules • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1001	12560
Ensembl	ENSG00000062038	ENSMUSG00000061048
UniProt	P22223	P10287
RefSeq (mRNA)	NM_001793 NM_001317195 NM_001317196	NM_001037809 NM_007665
RefSeq (protein)	NP_001304124 NP_001304125 NP_001784	NP_001032898 NP_031691
Location (UCSC)	Chr 16: 68.64 – 68.72 Mb	Chr 8: 106.51 – 106.56 Mb
PubMed search

4OY9

1001

12560

ENSG00000062038

ENSMUSG00000061048

P22223

P10287

NM_001793
NM_001317195
NM_001317196

NM_001037809
NM_007665

NP_001304124
NP_001304125
NP_001784

NP_001032898
NP_031691

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas.

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