Oxygenases

An oxygenase is any enzyme that oxidizes a substrate by transferring the oxygen from molecular oxygen O₂ (as in air) to it. The oxygenases form a class of oxidoreductases; their EC number is EC 1.13 or EC 1.14.

Oxygenases were discovered in 1955 simultaneously by two groups, Osamu Hayaishi from Japan and Howard S. Mason from the US. Hayaishi was awarded the 1986 Wolf Prize in Medicine "for the discovery of the oxygenase enzymes and elucidation of their structure and biological importance."

Oxygenases consist of both constitutive and inducible isozymes (HO-1, HO-2). These constitute a major intracellular source of iron and carbon monoxide

There are two types of oxygenases:

Among the most important monooxygenases are the , responsible for breaking down numerous chemicals in the body.

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