Otter Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of St. Francis River in Lake Wappapello.
The stream headwaters arise at 37°08′04″N 90°37′44″W / 37.13444°N 90.62889°W and the [[confluence with the St. Francis is at 36°59′03″N 90°22′49″W / 36.98417°N 90.38028°WCoordinates: 36°59′03″N 90°22′49″W / 36.98417°N 90.38028°W at an elevation of 358 feet (109 m).