Othon de la Roche, also Otho de la Roche (died before 1234), was a Burgundian nobleman from the castle of La Roche-sur-l'Ognon. He joined the Fourth Crusade and became the first Frankish Lord of Athens in 1204. In addition to Athens, he acquired Thebes by around 1211.
The chronicler Alberic of Trois-Fontaines writes that Othon was the son of "a certain noble Pons of La Roche in Burgundy". The identification of La Roche is uncertain, because Burgundy may refer either to the Free County or to the Duchy of Burgundy.La Roche-sur-l'Ognon, a hamlet by Rigney in the Free County, is the most probable candidate, because of its proximity to Flagey, Venise and other domains of Othon's family.
Othon confirmed his forefathers' donations to the Charlieu Abbey in 1195. He was with the Fourth Crusade on its arrival before the walls of Constantinople in 1203. At that time, he was a member of the "sixth division" of the crusading army, which "was formed by the people of Burgundy", according to the chronicler Geoffrey of Villehardouin. The crusaders captured Constantinople on 12 April 1204. They started the conquest of the Byzantine Empire under the command of Baldwin IX of Flanders who was elected the first Latin Emperor of Constantinople on 9 May.