Ōtaki Domain (大多喜藩 Ōtaki-han?) was a feudal domain under the Tokugawa shogunate of the Edo period, located in Kazusa Province (modern-day Chiba Prefecture), Japan. It was centered on Ōtaki Castle in what is now the town of Ōtaki, Chiba.
The original Ōtaki Castle was built by the Satomi clan, rulers of most of the Bōsō Peninsula during the Sengoku period. Following the Battle of Odawara in 1590, the Kantō region was assigned to Tokugawa Ieyasu by the warlord Toyotomi Hideyoshi, who also restricted the Satomi to Awa Province for their lukewarm support of his campaigns against the Late Hōjō clan. Tokugawa Ieyasu appointed Honda Tadakatsu, one of his Four Generals, to be daimyō of the newly formed 100,000 koku Ōtaki Domain.
Following the Battle of Sekigahara, Honda Tadakatsu was promoted to Kuwana Domain, and Ōtaki was assigned to Honda Tadatomo, from another branch of the Honda clan, with a reduction in revenues to 50,000 koku. Honda Tadatomo died at the Battle of Tennoji and his son, Honda Masatomo was reassigned to Tatsuno Domain in Harima Province.