Osteonectin

SPARC

Protein SPARC PDB 1bmo.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1BMO, 1NUB, 1SRA, 2V53

Identifiers

SPARC, BM-40, ON, OI17, secreted protein acidic and cysteine rich

External IDs

OMIM: 182120 MGI: 98373 HomoloGene: 31132 GeneCards: SPARC

Gene ontology
Molecular function	• calcium ion binding • collagen binding • metal ion binding • protein binding • extracellular matrix binding
Cellular component	• cytoplasm • platelet alpha granule • endocytic vesicle lumen • nuclear matrix • proteinaceous extracellular matrix • plasma membrane • intracellular • extracellular region • basement membrane • cell surface • platelet alpha granule membrane • mitochondrion • platelet alpha granule lumen • nucleus • extracellular space • vesicle
Biological process	• response to cytokine • response to cadmium ion • ossification • lung development • cellular response to growth factor stimulus • response to peptide hormone • platelet degranulation • extracellular matrix organization • response to L-ascorbic acid • response to glucocorticoid • wound healing • receptor-mediated endocytosis • negative regulation of endothelial cell proliferation • positive regulation of endothelial cell migration • response to calcium ion • response to gravity • heart development • response to lipopolysaccharide • response to lead ion • regulation of cell proliferation • negative regulation of angiogenesis • inner ear development • regulation of cell morphogenesis • response to cAMP • response to ethanol • bone development • signal transduction • pigmentation
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE SPARC 200665 s at tn.png

PBB GE SPARC 212667 at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


6678


20692


ENSG00000113140


ENSMUSG00000018593


P09486


P07214

RefSeq (mRNA)


NM_003118 NM_001309443 NM_001309444


NM_009242 NM_001290817

RefSeq (protein)


NP_001296372 NP_001296373 NP_003109


NP_033268.1 NP_001277746 NP_033268

Location (UCSC)

Chr 5: 151.66 – 151.69 Mb

Chr 11: 55.39 – 55.42 Mb

PubMed search

1BMO, 1NUB, 1SRA, 2V53

ENSG00000113140

ENSMUSG00000018593

NM_003118
NM_001309443
NM_001309444

NM_009242
NM_001290817

NP_001296372
NP_001296373
NP_003109

NP_033268.1
NP_001277746
NP_033268

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Wikipedia

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