Osteocalcin

BGLAP
Identifiers
Aliases	BGLAP, BGP, OC, OCN, bone gamma-carboxyglutamate protein
External IDs	OMIM: 112260 MGI: 88156 HomoloGene: 104130 GeneCards: BGLAP
Gene ontology Molecular function • calcium ion binding • structural molecule activity • metal ion binding • hydroxyapatite binding • structural constituent of bone Cellular component • cytoplasm • perikaryon • rough endoplasmic reticulum • Golgi apparatus • cell projection • endoplasmic reticulum lumen • extracellular region • dendrite • Golgi lumen • extracellular space • vesicle Biological process • skeletal system development • bone mineralization • response to vitamin D • response to organic cyclic compound • ossification • response to testosterone • regulation of bone mineralization • biomineral tissue development • cellular response to growth factor stimulus • response to mechanical stimulus • aging • response to zinc ion • response to glucocorticoid • cellular response to vitamin D • response to activity • response to estrogen • odontogenesis • cell aging • ER to Golgi vesicle-mediated transport • response to gravity • response to vitamin K • response to hydroxyisoflavone • signal peptide processing • cell adhesion • response to nutrient levels • regulation of osteoclast differentiation • osteoblast differentiation • response to inorganic substance • osteoblast development • peptidyl-glutamic acid carboxylation • response to ethanol • regulation of bone resorption • bone development • response to drug Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	632	12096
Ensembl	ENSG00000242252	ENSMUSG00000074483
UniProt	P02818	P86546
RefSeq (mRNA)	NM_199173	NM_001037939 NM_007541
RefSeq (protein)	NP_954642	NP_031567.1 NP_031567
Location (UCSC)	Chr 1: 156.24 – 156.24 Mb	Chr 3: 88.38 – 88.38 Mb
PubMed search

632

12096

ENSG00000242252

ENSMUSG00000074483

P02818

P86546

NM_199173

NM_001037939
NM_007541

NP_954642

NP_031567.1
NP_031567

Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. Because it has gla domains, its synthesis is vitamin K dependent. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A.

Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body's metabolic regulation and is pro-osteoblastic, or bone-building, by nature. It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin.

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Wikipedia