Opioid growth factor receptor

OGFR

Identifiers

OGFR, OGFr, opioid growth factor receptor

External IDs

MGI: 1919325 HomoloGene: 7199 GeneCards: OGFR

Gene ontology
Molecular function	• protein binding • receptor activity • opioid receptor activity
Cellular component	• membrane • cytoplasm • nucleus
Biological process	• regulation of growth • regulation of cell growth • opioid receptor signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


11054


72075

Ensembl


ENSG00000060491


ENSMUSG00000049401

UniProt


Q9NZT2


Q99PG2

RefSeq (mRNA)


NM_007346


NM_031373

RefSeq (protein)


NP_031372


NP_113550

Location (UCSC)

Chr 20: 62.8 – 62.81 Mb

Chr 2: 180.59 – 180.6 Mb

PubMed search

Opioid growth factor receptor (OGFr) conserved region

Identifiers

Symbol

OGFr_N

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Opioid growth factor receptor repeat

Identifiers

Symbol

OGFr_III

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Opioid growth factor receptor, also known as OGFr or the ζ-opioid receptor, is a protein which in humans is encoded by the OGFR gene. The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. The endogenous ligand is thus a known opioid peptide, and OGFr was originally discovered and named as a new opioid receptor zeta (ζ). However it was subsequently found that it shares little sequence similarity with the other opioid receptors, and has quite different function.

The natural function of this receptor appears to be in regulation of tissue growth, and it has been shown to be important in embryonic development, wound repair, and certain forms of cancer.

OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported.

...
Wikipedia