"Open Your Heart" is a song by American singer Madonna from her third studio album True Blue (1986). It was released as the album's fourth single in November 19, 1986 by Sire Records. It has since appeared remixed on the compilation albums The Immaculate Collection (1990) and Celebration (2009). Originally a rock and roll song titled "Follow Your Heart", it was written for singer Cyndi Lauper by songwriters Gardner Cole and Peter Rafelson, although it was never played to her. Since Madonna's management was looking for new songs for True Blue, she accepted it. Madonna altered some of the lyrics and changed the composition to suit the dance-pop genre, giving her a co-writer credit for the song. "Open Your Heart" is an innuendo-laden love song where Madonna expresses her sexual desire.

The song was well received by critics, who commended its simplicity. It was also successful commercially, reaching the top-ten of the charts in Belgium, Canada, Ireland, Italy, Netherlands, and the United Kingdom, and the top of the Billboard Hot 100 in the United States, thus making it Madonna's fifth number-one single in the US. The music video for "Open Your Heart" features a story line completely different from that of the song. In it, Madonna plays an exotic dancer in a peep-show club who befriends a little boy and subsequently escapes. It was critically acclaimed for subverting the male gaze, but the plot point of a child entering a strip club was criticized. The video is an homage to actresses Liza Minnelli and Marlene Dietrich.

"Open Your Heart" has been performed by Madonna in three of her world tours – Who's That Girl World Tour (1987), Blond Ambition World Tour (1990), where Madonna wore her infamous conical bra during the song, and The MDNA Tour (2012). The performances were included in the respective video release of the tours. "Open Your Heart" has been covered a number of times by different artists, and appeared in the Britney Spears film, Crossroads (2002).

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