One Night Stand (2008) was a professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE) that took place on June 1, 2008, at the San Diego Sports Arena in San Diego. It was the fourth and final event promoted under the One Night Stand name. The event featured talent from the Raw, SmackDown, and ECW brands.

The main match on the SmackDown! brand was a Tables, Ladders, and Chairs match for the vacant World Heavyweight Championship between Edge and The Undertaker, which Edge won after retrieving the belt suspended above the ring. Per the pre-match stipulation, Undertaker was forced to leave the WWE. The predominant match on the Raw brand was a Last Man Standing match for the WWE Championship between Triple H and Randy Orton, which Triple H won after Orton failed to answer the ten-count.

The primary match on the ECW brand was a Singapore Cane match involving The Big Show, CM Punk, John Morrison, Chavo Guerrero, and Tommy Dreamer. Big Show won the match after pinning Dreamer to become the number-one contender to the ECW Championship at Night of Champions. Featured matches on the undercard included Shawn Michaels versus Batista in a Stretcher match, and John Cena versus John "Bradshaw" Layfield in a First Blood match.