Night of Champions (2008) was a professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE) and presented by P&G's Gillette Fusion Power, which took place on June 29, 2008, at the American Airlines Center in Dallas, Texas. It was the first annual event to be promoted solely under the Night of Champions name and the eighth annual event under the Vengeance/Night of Champions chronology. It starred wrestlers from the Raw, SmackDown, and ECW brands. Like the previous year before, every match on the card was contested for a championship; three were won and five were retained.

The main event was an interpromotional match for the WWE Championship between SmackDown representative, Triple H, and Raw representative, John Cena; Triple H won the match and retained the championship. The main match was also an interpromotional match for the World Heavyweight Championship between SmackDown representative, Edge, and Raw representative, Batista, which Edge won to retain the championship. The main match from the ECW brand was an interpromotional standard match involving three wrestlers for the ECW Championship, in which ECW representative, Mark Henry, defeated the champion and Raw representative, Kane, and SmackDown representative, The Big Show.