Odo Shakiso is one of the woredas in the Oromia Region of Ethiopia. Part of the Guji Zone, Odo Shakiso is bordered on the south by the Dawa River which separates it from Arero, on the west by Hagere Mariam, on the northeast by Uraga, on the north by Bore, on the northeast by Adolana Wadera, and on the east by Liben. Towns in Odo Shakiso include Shakiso and Megado.
Two of the major mines of Ethiopia are located in Odo Shakiso: the Lega Dembi gold and the Kenticha tantalum mines, both near Shakiso. Gold has also been extracted by placer mining from the Awata River, which flows between Shakiso and Megado. A hydro-electric power station over the Mormora River was inaugurated by Emperor Haile Selassie in March 1965. Gold mining continues to be an important industry in this woreda, with the announcement 24 November 2009, that MIDROC Gold signed a 10-year agreement with the Ethiopian Ministry of Mines and Energy, for the extraction of almost 20.5 metric tons of gold from the Sakaro fields, three kilometers from the existing Lega Dembi mines. Between 1998 and 2008 MIDROC extracted 34 metric tons from the Lega Dembi mines, earning 466 million dollars; the new mine at Sakara is expected to bring a revenue of 564 million dollars, of which 130 million will go to the government as taxes and royalties.Coffee is an important cash crop in this woreda; over 5,000 hectares are planted with it.
Odo Shakiso was one of four woredas that suffered from a wildfire that was started 10 February 2000 and was not brought under control until 7 April, after it had burned a total of 70,000 hectares. The woreda suffered from another wildfire in early 2008, which burned over 2,500 hectares, including 60 hectares planted in coffee and enset. Losses to wild animals, the displacement of eight households and damages to bee hives were also reported.