OTX2

OTX2

Protein OTX2 PDB 2dms.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DMS

Identifiers

OTX2, CPHD6, MCOPS5, Orthodenticle homeobox 2

External IDs

MGI: 97451 HomoloGene: 11026 GeneCards: OTX2

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • eukaryotic initiation factor 4E binding
Cellular component	• growth cone • protein complex • nucleus
Biological process	• dopaminergic neuron differentiation • regulation of transcription, DNA-templated • positive regulation of gastrulation • protein complex assembly • regulation of fibroblast growth factor receptor signaling pathway • axon guidance • positive regulation of transcription, DNA-templated • multicellular organism development • regulation of smoothened signaling pathway • forebrain development • positive regulation of embryonic development • primitive streak formation • midbrain development • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE OTX2 gnf1h00384 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


5015


18424


ENSG00000165588


ENSMUSG00000021848


P32243


P80206

RefSeq (mRNA)


NM_001270523 NM_001270524 NM_001270525 NM_021728 NM_172337


NM_001286481 NM_001286482 NM_001286483 NM_144841

RefSeq (protein)


NP_001257452 NP_001257453 NP_001257454 NP_068374 NP_758840


n/a

Location (UCSC)

Chr 14: 56.8 – 56.81 Mb

Chr 14: 48.66 – 48.67 Mb

PubMed search

ENSG00000165588

ENSMUSG00000021848

NM_001270523
NM_001270524
NM_001270525
NM_021728
NM_172337

NM_001286481
NM_001286482
NM_001286483
NM_144841

NP_001257452
NP_001257453
NP_001257454
NP_068374
NP_758840

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Wikipedia

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