O-6-methylguanine-DNA methyltransferase

MGMT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EH6, 1EH7, 1EH8, 1QNT, 1T38, 1T39, 1YFH
Identifiers
Aliases	MGMT, Mgmt, AGT, AI267024, Agat, O-6-methylguanine-DNA methyltransferase
External IDs	MGI: 96977 HomoloGene: 31089 GeneCards: MGMT
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.3 Start 129,467,184 bp End 129,768,007 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 F3|7 82.07 cM Start 136,894,614 bp End 137,130,266 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • DNA binding • calcium ion binding • DNA-methyltransferase activity • metal ion binding • catalytic activity • methylated-DNA-[protein-cysteine S-methyltransferase activity] Cellular component • membrane • nucleoplasm • nucleus Biological process • response to organic cyclic compound • positive regulation of DNA repair • cellular response to organic cyclic compound • negative regulation of cell death • regulation of cysteine-type endopeptidase activity involved in apoptotic process • mammary gland epithelial cell differentiation • cellular response to DNA damage stimulus • DNA ligation • methylation • cellular response to ionizing radiation • cellular response to oxidative stress • response to folic acid • response to ethanol • response to toxic substance • response to drug • positive regulation of double-strand break repair • DNA repair • DNA methylation • negative regulation of apoptotic process • DNA dealkylation involved in DNA repair Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4255	17314
Ensembl	ENSG00000170430	ENSMUSG00000054612
UniProt	P16455	P26187
RefSeq (mRNA)	NM_002412	NM_008598
RefSeq (protein)	NP_002403	NP_032624
Location (UCSC)	Chr 10: 129.47 – 129.77 Mb	Chr 10: 136.89 – 137.13 Mb
PubMed search

'O6-alkylguanine DNA alkyltransferase'
Identifiers
EC number	2.1.1.63
CAS number	77271-19-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

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PMC	articles
PubMed	articles
NCBI	proteins

1EH6, 1EH7, 1EH8, 1QNT, 1T38, 1T39, 1YFH

4255

17314

ENSG00000170430

ENSMUSG00000054612

P16455

P26187

NM_002412

NM_008598

NP_002403

NP_032624

O⁶-alkylguanine DNA alkyltransferase (also known as AGT, MGMT or AGAT) is a protein that in humans is encoded by the O⁶-methylguanine DNA methyltransferase (MGMT) gene. O⁶-methylguanine DNA methyltransferase is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O⁶-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents. The two bacterial isozymes are Ada and Ogt.

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