Nuhašše, also Nuhašša, was a region in northwestern Syria that flourished in the 2nd millennium BC. It was a federacy ruled by different kings who collaborated and probably had a high king. Nuhašše changed hands between different powers in the region such as Egypt, Mitanni and the Hittites. It rebelled against the latter which led Šuppiluliuma I to attack and annex the region.
The name "Nuhašše" is Semitic meaning rich or prosperous. Nuhašše stretched from the Euphrates valley in the east to the Orontes valley in the west between Hamath in the south and Aleppo in the north; it did not include Ebla and it was separated from the Euphrates river by Emar and Ashtata. In the west, it reached the Orontes river only if it included the region of Niya which is debated. The main city was named Ugulzat (possibly modern Khan Shaykhun).Hittite texts mention the "Kings of Nuhašše", indicating that the region consisted of a number of petty kingdoms that might have formed a confederacy; one of the monarchs took the role of primus inter pares (first among equals), and resided in Ugulzat.
The majority of population in the second half of the second millennium BC was West-Semitic, while the ruling classes were Hurrians. The diplomatic language used in the region was a Hurrianized form of Akkadian as Hurrian traits appear in every Akkadian sentence in tablets written in Nuhašše; the Hurrian elements comprise around fifth of a sentence. The coronation of a king included anointing; a common practic in Bronze Age monarchies of Western Asia.
The name Nuhašše appeares in a bilingual Hittite-Hurrian text (named the Song of Release) which is copied from a Hurrian original dating to 2000 BC. In the Hurrian text, Nuhašše was a close ally of Ebla. The region was mentioned also in the archive of Mari and in the archive of Alalakh but did not designate a politically unified entity; at the times of Mari, the northern regions of Nuhašše were under the supremacy of Yamhad while the southern ones were subordinate to Qatna.Thutmose III annexed the region in the fifteenth century BC then Mitanni established its rule over the area.