In chemistry and physics, nucleons are the proton and the neutron, which are the constituents of the atomic nucleus, and are themselves composed of down and up quarks. The number of nucleons defines an isotope's mass number (nucleon number). The atom is made up of a nucleus surrounded by electrons.
Until the 1960s, nucleons were thought to be elementary particles, not made up of smaller parts. Now they are known to be composite particles, made of three quarks bound together by the so-called strong interaction. The interaction between two or more nucleons is called internucleon interactions or nuclear force, which is also ultimately caused by the strong interaction. (Before the discovery of quarks, the term "strong interaction" referred to just internucleon interactions.)
Nucleons sit at the boundary where particle physics and nuclear physics overlap. Particle physics, particularly quantum chromodynamics, provides the fundamental equations that explain the properties of quarks and of the strong interaction. These equations explain quantitatively how quarks can bind together into protons and neutrons (and all the other hadrons). However, when multiple nucleons are assembled into an atomic nucleus (nuclide), these fundamental equations become too difficult to solve directly (see lattice QCD). Instead, nuclides are studied within nuclear physics, which studies nucleons and their interactions by approximations and models, such as the nuclear shell model. These models can successfully explain nuclide properties, for example, whether or not a certain nuclide undergoes radioactive decay.