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Nodular lymphocyte predominant Hodgkin's lymphoma

Nodular lymphocyte predominant Hodgkin's lymphoma
Popcorn cell in nodular lymphocyte predominant Hodgkin lymphoma - very high mag cropped.jpg
Micrograph of a lymph node biopsy showing nodular lymphocyte predominant Hodgkin lymphoma, with the Reed–Sternberg cell variant that has a popcorn-shaped nucleus (left-bottom of image). H&E stain.
Classification and external resources
Specialty Hematology and oncology
ICD-10 C81.0
ICD-9-CM 201.9
ICD-O M9659/3
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Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a form of lymphoma.

Some people no longer classified it as a form of classic Hodgkin's lymphoma (HL). This is because the Reed-Sternberg Cell (RSC) variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma.

There are small but clear differences in prognosis between the various forms. Lymphocyte predominant HL is an uncommon subtype composed of vague nodules of numerous reactive lymphocytes admixed with large popcorn-shaped RSC. Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. The anti-CD20 monoclonal antibody Rituximab has been used in lymphocyte predominant Hodgkin's lymphoma with encouraging results.

BCL6 gene rearrangements have been frequently observed.


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