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Nodal (protein)

NODAL
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NODAL, HTX5, nodal growth differentiation factor
External IDs MGI: 97359 HomoloGene: 8417 GeneCards: NODAL
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018055
NM_001329906

NM_013611

RefSeq (protein)

NP_001316835
NP_060525

NP_038639

Location (UCSC) Chr 10: 70.43 – 70.45 Mb Chr 10: 61.42 – 61.43 Mb
PubMed search

4N1D

NM_018055
NM_001329906

NM_013611

NP_001316835
NP_060525

NP_038639

Nodal is a secretory protein that in humans is encoded by the NODAL gene which is located on chromosome 10q22.1. It belongs to the Transforming Growth Factor (TGF-β) superfamily. Like many other members of this superfamily it is involved in cell differentiation in early embryogenesis, playing a key role in signal transfer from the node, in the anterior primitive streak, to lateral plate mesoderm (LPM).


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