Nociceptin receptor

OPRL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EA3, 5DHG, 5DHH
Identifiers
Aliases	OPRL1, KOR-3, NOCIR, OOR, ORL1, NOP, NOPr, opioid related nociceptin receptor 1
External IDs	OMIM: 602548 MGI: 97440 HomoloGene: 22609 GeneCards: OPRL1
Gene ontology Molecular function • G-protein coupled receptor activity • nociceptin receptor activity • neuropeptide binding • signal transducer activity • opioid receptor activity • protein C-terminus binding • protein binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • neuron projection • cytoplasmic vesicle Biological process • G-protein coupled receptor signaling pathway • positive regulation of protein phosphorylation • response to estradiol • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • sensory perception • behavior • positive regulation of urine volume • eating behavior • regulation of sensory perception of pain • negative regulation of blood pressure • estrous cycle • regulation of locomotor rhythm • positive regulation of cytosolic calcium ion concentration • positive regulation of gastric acid secretion • positive regulation of sensory perception of pain • negative regulation of cAMP biosynthetic process • sensory perception of pain • negative regulation of voltage-gated calcium channel activity • regulation of cAMP biosynthetic process • neuropeptide signaling pathway • signal transduction • chemical synaptic transmission • opioid receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4987	18389
Ensembl	n/a	ENSMUSG00000027584
UniProt	P41146	P35377
RefSeq (mRNA)	NM_000913 NM_001200019 NM_182647 NM_001318853 NM_001318854 NM_001318855	NM_001252565 NM_011012 NM_001318919 NM_001318920 NM_001318922 NM_001318923 NM_001318924 NM_001318925
RefSeq (protein)	NP_000904 NP_001186948 NP_001305782 NP_001305783 NP_001305784 NP_872588	NP_001239494.1 NP_035142.1 NP_001305848.1 NP_001305849.1 NP_001239494 NP_001305848 NP_001305849 NP_001305851 NP_001305852 NP_001305853 NP_001305854 NP_035142
Location (UCSC)	Chr 20: 64.08 – 64.1 Mb	Chr 2: 181.72 – 181.72 Mb
PubMed search

4EA3, 5DHG, 5DHH

4987

18389

n/a

ENSMUSG00000027584

P41146

P35377

NM_001318855

NM_001318923
NM_001318924
NM_001318925

NP_872588

NP_001305848
NP_001305849
NP_001305851
NP_001305852
NP_001305853
NP_001305854
NP_035142

The nociceptin receptor (NOP)_, also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene. The nociceptin receptor is a member of the opioid subfamily of G protein-coupled receptors whose natural ligand is the 17 amino acid neuropeptide known as nociceptin (N/OFQ). This receptor is involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors.

...
Wikipedia