Nitric oxide synthase 2 (inducible)

NOS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS
Identifiers
Aliases	NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDs	MGI: 97361 HomoloGene: 55473 GeneCards: NOS2
Genetically Related Diseases
psoriasis
Targeted by Drug
pimagedine, nitroarginine,
Gene ontology Molecular function • FMN binding • protein homodimerization activity • flavin adenine dinucleotide binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • protein binding • heme binding • NADP binding • oxidoreductase activity • receptor binding • nitric-oxide synthase activity • NADPH-hemoprotein reductase activity Cellular component • cytoplasm • cytosol • cortical cytoskeleton • peroxisome • intracellular • perinuclear region of cytoplasm • nucleus Biological process • positive regulation of guanylate cyclase activity • response to hypoxia • nitric oxide biosynthetic process • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • negative regulation of protein catabolic process • regulation of insulin secretion • negative regulation of blood pressure • regulation of cytokine production involved in inflammatory response • positive regulation of killing of cells of other organism • negative regulation of gene expression • cell redox homeostasis • arginine catabolic process • prostaglandin secretion • interleukin-6 secretion • response to lipopolysaccharide • cellular response to drug • innate immune response in mucosa • regulation of cell proliferation • peptidyl-cysteine S-nitrosylation • defense response to bacterium • circadian rhythm • defense response to Gram-negative bacterium • nitric oxide mediated signal transduction • interleukin-8 secretion • cellular response to interferon-gamma • regulation of cellular respiration • cellular response to lipopolysaccharide • oxidation-reduction process • superoxide metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4843	18126
Ensembl	ENSG00000007171	ENSMUSG00000020826
UniProt	P35228	P29477
RefSeq (mRNA)	NM_000625 NM_153292	NM_010927 NM_001313921 NM_001313922
RefSeq (protein)	NP_000616	NP_001300850.1 NP_001300851.1 NP_035057.1 NP_001300850 NP_001300851 NP_035057
Location (UCSC)	Chr 17: 27.76 – 27.8 Mb	Chr 11: 78.92 – 78.96 Mb
PubMed search

1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS

4843

18126

ENSG00000007171

ENSMUSG00000020826

P35228

P29477

NM_000625
NM_153292

NM_010927
NM_001313921
NM_001313922

NP_000616

NP_035057

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.

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