Nitric oxide synthase 2A

NOS2

PDB 1nsi EBI.jpg

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS

Identifiers

NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2

External IDs

MGI: 97361 HomoloGene: 55473 GeneCards: NOS2

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	No data available	Start	27,756,766 bp
Band	No data available	End	27,800,499 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	No data available	Start	78,920,787 bp
Band	No data available	End	78,960,254 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• FMN binding • protein homodimerization activity • flavin adenine dinucleotide binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • protein binding • heme binding • oxidoreductase activity • receptor binding • nitric-oxide synthase activity • NADPH-hemoprotein reductase activity • iron ion binding • NADP binding
Cellular component	• cytoplasm • cytosol • cortical cytoskeleton • peroxisome • intracellular • perinuclear region of cytoplasm • nucleus
Biological process	• positive regulation of guanylate cyclase activity • response to hypoxia • nitric oxide biosynthetic process • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • negative regulation of protein catabolic process • regulation of insulin secretion • negative regulation of blood pressure • regulation of cytokine production involved in inflammatory response • positive regulation of killing of cells of other organism • negative regulation of gene expression • cell redox homeostasis • arginine catabolic process • prostaglandin secretion • interleukin-6 secretion • response to lipopolysaccharide • cellular response to drug • innate immune response in mucosa • regulation of cell proliferation • peptidyl-cysteine S-nitrosylation • defense response to bacterium • circadian rhythm • defense response to Gram-negative bacterium • nitric oxide mediated signal transduction • interleukin-8 secretion • cellular response to interferon-gamma • regulation of cellular respiration • cellular response to lipopolysaccharide • oxidation-reduction process • superoxide metabolic process • positive regulation of blood vessel diameter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


4843


18126


ENSG00000007171


ENSMUSG00000020826


P35228


P29477

RefSeq (mRNA)


NM_000625 NM_153292


NM_010927 NM_001313921 NM_001313922

RefSeq (protein)


NP_000616


NP_001300850 NP_001300851 NP_035057

Location (UCSC)

Chr 17: 27.76 – 27.8 Mb

Chr 11: 78.92 – 78.96 Mb

PubMed search

1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS

ENSG00000007171

ENSMUSG00000020826

NM_000625
NM_153292

NM_010927
NM_001313921
NM_001313922

NP_001300850
NP_001300851
NP_035057

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Wikipedia

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