"Nite and Day" is a 1988 single by Al B. Sure! from the Warner Bros. album In Effect Mode. It reached number seven on the Hot 100 and number one on the Hot Black Singles chart.

The song was executive produced by Benny Medina and Andre Harrell. It was produced, arranged and musically programmed by Kyle West for Key West International, co-produced and written by Al B. Sure! and Teddy Riley for Al B. Sure! International and Uptown Enterprises. The song was recorded at Unique Recording Studios. The song was mixed by Roey Shamir for INFX Production inc. The single earned him a nomination for a Grammy Award for Best Male R&B Vocal Performance at the 31st Grammy Awards in 1989, losing to Introducing the Hardline According to Terence Trent D'Arby by Terence Trent D'Arby.

The B side of most printing of the 45 have the song sung in French;Nuit Et Jour.

In 2009, a cover version by Raheem DeVaughn was leaked as a song off his new "Love & War" mixtape. In 2012, a cover version by EL Seven/Universal Recording artist Adrian Marcel was leaked with in studio Video.

R&B and hip-hop duo P.M. Dawn sampled this song on the single "Sometimes I Miss You So Much", from the 1995 album Jesus Wept. They also had Al B. Sure featured on the music video that was shot for the song.

Elements of the song were sampled for L.L. Cool J's Loungin' from the album Mr. Smith.

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