Nishi-Ōhira Domain (西大平藩 Nishi-Ōhira han?) was a Japanese feudal domain of the Edo period Tokugawa shogunate, located in Nukata District Mikawa Province (part of modern-day Aichi Prefecture), Japan. It was centered on what is now part of the city of Okazaki, Aichi.
Ōoka Tadasuke, the famous magistrate who had served the 9th Tokugawa Shogun, Tokugawa Yoshimune, and who had successfully carried out the Kyōhō Reforms received an additional 4,000 koku in revenue on his promotion to sōshaban in 1748. This put him over the 10,000 koku requirement to be styled as daimyō, and he received the newly created fief of Nishi-Ōhira as his domain. However, he never relocated to his new territory, and resided in Edo to his death in 1757.
Nishi-Ōhira Domain was not a single contiguous territory, but consisted of several widely scattered holdings: in addition to 12 villages in Nukata District, the territory consisted of 5 villages in Kamo District, 5 villages in Hoi District, 2 villages in Omi District in Mikawa, 3 villages in Ichihara District, Kazusa Province and the original 2 villages of the Ōoka clan in Kōza District, Sagami Province.