Night of Champions was a professional wrestling pay-per-view (PPV) event produced by WWE, which took place on September 16, 2012 at the TD Garden in Boston, Massachusetts. It was presented by Lions Gate Entertainment's Dredd and was the fifth annual WWE Night of Champions event (sixth including Vengeance: Night of Champions) and the thirteenth in the WWE Vengeance/Night of Champions overall chronology. The theme to the Night of Champions event is that all sanctioned championships are defended on the card. The event managed to gain 189,000 buys. That is up from last year's event, which gained a 169,000 buyrate.

The professional wrestling matches at Night of Champions featured professional wrestlers performing as characters in scripted events pre-determined by the hosting promotion, WWE. Storylines between the characters played out on WWE's primary television programs, Raw and SmackDown.

Upon losing to Sheamus again at SummerSlam, Alberto Del Rio felt that because the referee didn't see his foot on the bottom rope during the pin, he deserved another title match. Sheamus felt that Del Rio had enough chances to beat him and said that Randy Orton, who just returned from suspension, deserved a title shot. Del Rio defeated Orton to earn a title match at the event.

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