Night of Champions (2010) was a professional wrestling pay-per-view event produced by World Wrestling Entertainment (WWE) and presented by WowWee's Paper Jamz, that took place on September 19, 2010, at the Allstate Arena in Rosemont, Illinois. It was the third annual event to be promoted solely under the Night of Champions name and the tenth annual event under the Vengeance/Night of Champions chronology. Similar to the previous three events, the concept of the show was that every championship in the company was defended at the event. It was also the first Night of Champions event to feature a non-title match. Seven matches took place at the event. The event had 165,000 buys, down on the 2009's Night of Champions figure of 267,000 buys.

Night of Champions featured professional wrestling matches involving different wrestlers from pre-existing scripted feuds, plots, and storylines that played out on World Wrestling Entertainment's (WWE) television programs. Wrestlers portrayed villains or heroes as they followed a series of events that built tension and culminated in a wrestling match or series of matches.