Nierstein-Oppenheim is a former Verbandsgemeinde ("collective municipality") in the district Mainz-Bingen (Rheinhessen) in Rhineland-Palatinate, Germany. It is situated on the left bank of the Rhine, approx. 15 km south-east of Mainz. On 1 July 2014 it merged into the new Verbandsgemeinde Rhein-Selz.
The Verbandsgemeinde consisted of the following eleven Ortsgemeinden ("local municipalities"):
Coordinates: 49°51′N 8°22′E / 49.850°N 8.367°E