The Nicholas Building is a landmark historic office and retail building located at 37 Swanston St, at the intersection of Swanston Street and Flinders Lane, in the heart of Melbourne, Australia. Designed by architect Harry Norris as an investment for the Nicholas family, headed by Alfred Nicholas, and completed in 1926, it is the grandest example of what is known as the 'Chicago School' or 'Commercial Palazzo' style, featuring large scale classical elements. It has long housed a range of small businesses, and is now known for its creative industry tenants such as fashion designers and artists and specialist retailers. It had the longest operating manual lifts in the city, and the ground floor Cathedral Arcade is one of the most notable arcades in the city.
The Nicholas family, headed by Alfred Nicholas, built their fortune on the production of Aspro, a replacement for the German-made aspirin when it became unavailable during World War I. The Nicholas company never occupied the building; it was instead built as a speculative office building development. It was completed in 1926, and designed by architect Harry Norris. Harry Norris established his architecture practice in the building, remaining until his retirement in the mid-fifties. From 1926 to 1967 a Coles department store occupied the basement and part of the ground floor. The building was home to businesses associated with the Flinders Lane garment trade, commercial artists, medical practitioners and architects. By the 2010's the small rooms and relatively cheap rent attracted creative industry practitioners and specialist retailers, some of whom still serve the fashion industry, and it became renowned as one of Melbourne's 'vertical lanes'.
The novel Shantaram, written by one of Australia’s most wanted fugitives Gregory David Roberts, was written in the building. In 2003 it is believed a stencil by UK artist Banksy was painted on the building at the corner of Swanston St and Flinders Lane; a piece of plastic was put up over the piece to protect it from the elements but was later painted over by vandals causing a disturbance in the art community.