Nicastrin

NCSTN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4UPC, 5A63, 4UIS, 5FN3, 5FN4, 5FN5, 5FN2, 2N7R, 2N7Q

Identifiers

NCSTN, ATAG1874, nicastrin

External IDs

OMIM: 605254 MGI: 1891700 HomoloGene: 41029 GeneCards: NCSTN

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q23.2	Start	160,343,272 bp
Band	1q23.2	End	160,358,952 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1 H3\|1 79.54 cM	Start	172,066,013 bp
Band	1 H3\|1 79.54 cM	End	172,082,795 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• peptidase activity • protein binding • endopeptidase activity
Cellular component	• Golgi apparatus • membrane • focal adhesion • melanosome • plasma membrane • integral component of plasma membrane • lysosomal membrane • endoplasmic reticulum • extracellular exosome • integral component of membrane • azurophil granule membrane • gamma-secretase complex • cytoplasmic vesicle membrane • cytoplasmic vesicle
Biological process	• Notch signaling pathway • ephrin receptor signaling pathway • myeloid cell homeostasis • protein processing • positive regulation of catalytic activity • amyloid-beta metabolic process • epithelial cell proliferation • proteolysis • T cell proliferation • membrane protein ectodomain proteolysis • membrane protein intracellular domain proteolysis • positive regulation of apoptotic process • Notch receptor processing • amyloid precursor protein catabolic process • amyloid-beta formation • amyloid precursor protein metabolic process • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


23385


59287


ENSG00000162736


ENSMUSG00000003458


Q92542


P57716

RefSeq (mRNA)


NM_001290184 NM_001290186 NM_015331 NM_001349729


NM_021607

RefSeq (protein)


NP_001277113 NP_001277115 NP_056146 NP_001336658


NP_067620

Location (UCSC)

Chr 1: 160.34 – 160.36 Mb

Chr 1: 172.07 – 172.08 Mb

PubMed search

4UPC, 5A63, 4UIS, 5FN3, 5FN4, 5FN5, 5FN2, 2N7R, 2N7Q

ENSG00000162736

ENSMUSG00000003458

NM_001290184
NM_001290186
NM_015331
NM_001349729

NP_001277113
NP_001277115
NP_056146
NP_001336658

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Wikipedia

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