New York State Route 221

New York State Route 221
Map of Cortland County and vicinity with NY 221 highlighted in red and NY 200 highlighted in light red
Route information
Maintained by NYSDOT
Length:	18.71 mi (30.11 km)
Existed:	1930 – present
Major junctions
West end:	NY 38 in Harford
	I-81 in Marathon
East end:	NY 26 / NY 41 in Willet
Location
Counties:	Cortland
Highway system
New York Highways Interstate U.S. State Reference Parkways ← NY 220 NY 222 → ← NY 199 NY 201 →

New York State Route 221 (NY 221) is a state highway in Cortland County, New York, in the United States. Its western terminus is at an intersection with NY 38 in the town of Harford. The eastern terminus is at a junction with NY 26 and NY 41 in the town of Willet. Near its western end, NY 221 intersects New York State Route 200. Together, NY 200 and NY 221 form a loop route off NY 38 between the hamlets of Harford and Harford Mills within the town of Harford. NY 221 originally followed modern NY 200 and ended at U.S. Route 11 (US 11) in Marathon when it was assigned as part of the 1930 renumbering of state highways in New York. It was extended to its present length by the following year and realigned to serve Harford later in the decade. NY 200 was assigned in the 1940s.

NY 221 begins at an intersection with NY 38 in the town of Harford. The route progresses northward through a small hamlet, crossing the Owego and Harford Railway and serving a mobile home park. At the intersection with Owego Hill Road, NY 221 turns eastward as a two-lane road, where the route changes backdrops into a more rural and residential mix. After about a mile, the route intersects with NY 200, a 1.37-mile long (2.20 km) route that connects NY 221 back to NY 38 and the hamlet of Harford Mills. At this junction, NY 221 turns north once again, while NY 200 begins on the former right-of-way used by NY 221. The surroundings remain the same as the route continues, turning to the northeast, and soon east at the junction at County Route 131 (CR 131; Babcock Hollow Road).