Neutrophil elastase

ELANE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B0F, 1H1B, 1HNE, 1PPF, 1PPG, 2RG3, 2Z7F, 3Q76, 3Q77, 4NZL, 4WVP, 5A09, 5A0A, 5A0B, 5A0C, 5ABW
Identifiers
Aliases	ELANE, ELA2, GE, HLE, HNE, NE, PMN-E, SCN1, elastase, neutrophil expressed
External IDs	OMIM: 130130 MGI: 2679229 HomoloGene: 20455 GeneCards: ELANE
Targeted by Drug
sivelestat
Gene ontology Molecular function • RNA polymerase II transcription corepressor activity • heparin binding • endopeptidase activity • protease binding • peptidase activity • protein binding • serine-type peptidase activity • hydrolase activity • cytokine binding • serine-type endopeptidase activity Cellular component • cytoplasm • transcriptional repressor complex • secretory granule • extracellular region • cell surface • extracellular exosome • extracellular space • azurophil granule lumen • specific granule lumen Biological process • response to yeast • positive regulation of MAP kinase activity • negative regulation of growth of symbiont in host • negative regulation of chemotaxis • cellular calcium ion homeostasis • extracellular matrix disassembly • acute inflammatory response to antigenic stimulus • negative regulation of transcription from RNA polymerase II promoter • negative regulation of interleukin-8 biosynthetic process • defense response to fungus • proteolysis • response to lipopolysaccharide • positive regulation of immune response • protein catabolic process • defense response to bacterium • phagocytosis • neutrophil mediated killing of fungus • negative regulation of chemokine biosynthetic process • positive regulation of interleukin-8 biosynthetic process • negative regulation of inflammatory response • response to UV • leukocyte migration • positive regulation of smooth muscle cell proliferation • leukocyte migration involved in inflammatory response • positive regulation of leukocyte tethering or rolling • antimicrobial humoral response • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1991	50701
Ensembl	n/a	ENSMUSG00000020125
UniProt	P08246	Q3UP87
RefSeq (mRNA)	NM_001972	NM_015779
RefSeq (protein)	NP_001963	NP_056594.2 NP_056594
Location (UCSC)	Chr 19: 0.85 – 0.86 Mb	Chr 10: 79.89 – 79.89 Mb
PubMed search

1B0F, 1H1B, 1HNE, 1PPF, 1PPG, 2RG3, 2Z7F, 3Q76, 3Q77, 4NZL, 4WVP, 5A09, 5A0A, 5A0B, 5A0C, 5ABW

1991

50701

n/a

ENSMUSG00000020125

P08246

Q3UP87

NM_001972

NM_015779

NP_001963

...
Wikipedia