Neuropeptide Y

NPY
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RON, 1QFA
Identifiers
Aliases	NPY, PYY4, Neuropeptid Y gene, neuropeptide Y
External IDs	OMIM: 162640 MGI: 97374 HomoloGene: 697 GeneCards: NPY
Gene ontology Molecular function • G-protein coupled receptor activity • hormone activity • calcium channel regulator activity • neuropeptide hormone activity • receptor binding • G-protein coupled receptor binding Cellular component • cytoplasm • Golgi apparatus • cell • extracellular region • extracellular space Biological process • positive regulation of appetite • response to yeast • movement of cell or subcellular component • adult feeding behavior • behavior • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • antibacterial humoral response • blood circulation • regulation of blood pressure • central nervous system neuron development • defense response to Gram-negative bacterium • feeding behavior • cerebral cortex development • regulation of appetite • cell proliferation • innate immune response • neuropeptide signaling pathway • neuron projection development • calcium ion transport • antifungal humoral response • defense response to Gram-positive bacterium • chemical synaptic transmission • digestion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4852	109648
Ensembl	ENSG00000122585	ENSMUSG00000029819
UniProt	P01303	P57774
RefSeq (mRNA)	NM_000905	NM_023456
RefSeq (protein)	NP_000896	NP_075945.1 NP_075945
Location (UCSC)	Chr 7: 24.28 – 24.29 Mb	Chr 6: 49.82 – 49.83 Mb
PubMed search

Neuropeptide Y

Identifiers
CAS Number	82785-45-3 N
ChemSpider	none
ChEMBL	CHEMBL267633 N
Chemical and physical data
Formula	C190H287N55O57
Molar mass	4253.7 g/mol
NY (what is this?)

1RON, 1QFA

4852

109648

ENSG00000122585

ENSMUSG00000029819

P01303

P57774

NM_000905

NM_023456

NP_000896

NP_075945.1
NP_075945

Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that acts as a neurotransmitter in the brain and in the autonomic nervous system of humans; slight variations of the peptide are found in many other animals. In the autonomic system it is produced mainly by neurons of the sympathetic nervous system and serves as a strong vasoconstrictor and also causes growth of fat tissue. In the brain, it is produced in various locations including the hypothalamus, and is thought to have several functions, including: increasing food intake and storage of energy as fat, reducing anxiety and stress, reducing pain perception, affecting the circadian rhythm, reducing voluntary alcohol intake, lowering blood pressure, and controlling epileptic seizures.

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