Neurogenic inflammation

Neurogenic inflammation is inflammation arising from the local release of inflammatory mediators from afferent neurons such as Substance P, Calcitonin Gene-Related Peptide (CGRP), neurokinin A (NKA), and endothelin-3 (ET-3).TRPA1 channels stimulated by lipopolysaccharide (LPS) may also cause acute neurogenic inflammation.

Neurogenic inflammation appears to play an important role in the pathogenesis of numerous diseases including migraine,psoriasis,asthma, vasomotor rhinitis,fibromyalgia, eczema, rosacea, dystonia, and multiple chemical sensitivity.

In migraine, stimulation of the trigeminal nerve causes neurogenic inflammation via release of neuropeptides including Substance P, nitric oxide, vasoactive intestinal polypeptide, 5-HT, Neurokinin A and CGRP. leading to a "sterile neurogenic inflammation."

In a 2012 article in Nature Neuroscience Chiu et al. discuss the development of science related to neurogenic inflammation and provide a graphic illustrating key discoveries leading toward the current understanding of neurogenic inflammation, its mechanisms, and the conditions caused by its disorder.

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