Neprilysin

MME

Neprilysin 1r1h.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9, 4CTH, 5JMY

Identifiers

MME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase

External IDs

OMIM: 120520 MGI: 97004 HomoloGene: 5275 GeneCards: MME

Gene ontology
Molecular function	• protein binding • zinc ion binding • exopeptidase activity • hydrolase activity • endopeptidase activity • metal ion binding • peptidase activity • peptide binding • metalloendopeptidase activity • metallopeptidase activity
Cellular component	• brush border • focal adhesion • integral component of plasma membrane • cytoplasm • membrane • extracellular exosome • integral component of membrane • synaptic vesicle • plasma membrane • synapse • axon • dendrite • neuron projection terminus • secretory granule membrane
Biological process	• angiotensin maturation • cellular response to UV-B • cellular response to cytokine stimulus • kidney development • replicative senescence • cellular response to UV-A • creatinine metabolic process • peptide metabolic process • beta-amyloid metabolic process • proteolysis • sensory perception of pain • neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE MME 203434 s at tn.png

PBB GE MME 203435 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


4311


17380


ENSG00000196549


ENSMUSG00000027820


P08473 Q3KQS6


Q61391

RefSeq (mRNA)


NM_000902 NM_007287 NM_007288 NM_007289


NM_008604 NM_001289462 NM_001289463

RefSeq (protein)


NP_000893 NP_009218 NP_009219 NP_009220

NP_001276391.1 NP_001276392.1 NP_032630.2 NP_001276391 NP_001276392
NP_032630

Location (UCSC)

Chr 3: 155.02 – 155.18 Mb

Chr 3: 63.24 – 63.39 Mb

PubMed search

1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9, 4CTH, 5JMY

ENSG00000196549

ENSMUSG00000027820

NM_000902
NM_007287
NM_007288
NM_007289

NM_008604
NM_001289462
NM_001289463

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Wikipedia

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