Nectin-1

NECTIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ALP, 3SKU, 3U83, 4FMF, 4MYW
Identifiers
Aliases	NECTIN1, CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1, PVRL1, nectin cell adhesion molecule 1
External IDs	MGI: 1926483 HomoloGene: 2138 GeneCards: NECTIN1
Gene ontology Molecular function • protein homodimerization activity • coreceptor activity • virus receptor activity • protein binding • protein heterodimerization activity • virion binding • receptor binding • carbohydrate binding • receptor activity • cell adhesion molecule binding • identical protein binding Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle • plasma membrane • growth cone membrane • synapse • integral component of plasma membrane • cell-cell adherens junction • extracellular region • axon • cell junction • neuron projection • catenin complex • presynaptic membrane • adherens junction • apical junction complex • cell-cell contact zone Biological process • single organismal cell-cell adhesion • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • cell recognition • desmosome organization • regulation of synapse assembly • axon guidance • cell adhesion • iron ion transport • lens morphogenesis in camera-type eye • retina development in camera-type eye • immune response • viral entry into host cell • enamel mineralization • viral process • adherens junction organization • camera-type eye morphogenesis • homophilic cell adhesion via plasma membrane adhesion molecules • signal transduction • protein localization to cell junction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5818	58235
Ensembl	ENSG00000110400	ENSMUSG00000032012
UniProt	Q15223	Q9JKF6
RefSeq (mRNA)	NM_203286 NM_002855 NM_032767 NM_203285	NM_021424
RefSeq (protein)	NP_002846 NP_976030 NP_976031	NP_067399
Location (UCSC)	Chr 11: 119.62 – 119.73 Mb	Chr 9: 43.74 – 43.81 Mb
PubMed search

3ALP, 3SKU, 3U83, 4FMF, 4MYW

5818

58235

ENSG00000110400

ENSMUSG00000032012

Q15223

Q9JKF6

NM_203286
NM_002855
NM_032767
NM_203285

NM_021424

NP_002846
NP_976030
NP_976031

NP_067399

Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins. It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca²⁺-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).

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