Naglazyme

ARSB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FSU

Identifiers

Aliases

ARSB, arylsulfatase B, ASB, G4S, MPS6

External IDs

MGI: 88075 HomoloGene: 73870 GeneCards: ARSB

Gene ontology
Molecular function	• metal ion binding • arylsulfatase activity • catalytic activity • N-acetylgalactosamine-4-sulfatase activity • sulfuric ester hydrolase activity • hydrolase activity
Cellular component	• rough endoplasmic reticulum • Golgi apparatus • endoplasmic reticulum lumen • cell surface • lysosomal lumen • mitochondrion • lysosome • extracellular exosome • extracellular region • azurophil granule lumen • ficolin-1-rich granule lumen
Biological process	• glycosphingolipid metabolic process • response to nutrient • post-translational protein modification • response to estrogen • autophagy • regulation of epithelial cell migration • central nervous system development • colon epithelial cell migration • positive regulation of neuron projection development • response to pH • chondroitin sulfate catabolic process • lysosomal transport • metabolic process • response to methylmercury • lysosome organization • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


411


11881

Ensembl


ENSG00000113273


ENSMUSG00000042082

UniProt


P15848


P50429

RefSeq (mRNA)


NM_000046 NM_198709


NM_009712

RefSeq (protein)


NP_000037 NP_942002


NP_033842

Location (UCSC)

Chr 5: 78.78 – 78.99 Mb

Chr 13: 93.77 – 93.94 Mb

PubMed search

arylsulfatase B
Crystallographic structure of putative tetrameric arylsulfatase from Escherichia coli.
Identifiers
Symbol	ARSB
Entrez	411
HUGO	714
OMIM	253200
RefSeq	NM_000046
UniProt	P15848
Other data
EC number	3.1.6.12
Locus	Chr. 5 p11-q13

Arylsulfatase B (N-acetylgalactosamine-4-sulfatase, chondroitinsulfatase, chondroitinase, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, EC 3.1.6.12) is an enzyme associated with mucopolysaccharidosis VI (Maroteaux–Lamy syndrome).

Arylsulfatase B is among a group of arylsulfatase enzymes present in the lysosomes of the liver, pancreas, and kidneys of animals. The purpose of the enzyme is to hydrolyze sulfates in the body. ARSB does this by breaking down glycosaminoglycans(GAGs), which are large sugar molecules in the body. ARSB targets two GAGs in particular: dermatan sulfate and chondroitin sulfate.

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