NUMB (gene)

NUMB

Protein NUMB PDB 1wj1.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WJ1

Identifiers

NUMB, C14orf41, S171, c14_5527, endocytic adaptor protein

External IDs

MGI: 107423 HomoloGene: 2775 GeneCards: NUMB

Genetically Related Diseases

bipolar disorder, coronary artery disease

Gene ontology
Molecular function	• beta-catenin binding • protein binding • alpha-catenin binding • cadherin binding
Cellular component	• cytoplasm • membrane • focal adhesion • plasma membrane • apical part of cell • basolateral plasma membrane • early endosome • extrinsic component of plasma membrane • nucleus • clathrin-coated vesicle • cytoplasmic vesicle
Biological process	• neuroblast division in subventricular zone • lateral ventricle development • axonogenesis • positive regulation of cell migration • nervous system development • multicellular organism development • positive regulation of neurogenesis • negative regulation of protein localization to plasma membrane • neuroblast proliferation • lung epithelial cell differentiation • positive regulation of polarized epithelial cell differentiation • forebrain development • adherens junction organization • negative regulation of Notch signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE NUMB 207545 s at fs.png

PBB GE NUMB 209073 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


8650


18222


ENSG00000133961


ENSMUSG00000021224


P49757


Q9QZS3

RefSeq (mRNA)


NM_001005743 NM_001005744 NM_001005745 NM_003744 NM_001320114


NM_001136075 NM_001272055 NM_001272056 NM_010949

RefSeq (protein)


NP_001005743 NP_001005744 NP_001005745 NP_001307043 NP_003735

NP_001129547.1 NP_001258984.1 NP_001258985.1 NP_035079.1 NP_001129547
NP_001258984 NP_001258985 NP_035079

Location (UCSC)

Chr 14: 73.28 – 73.46 Mb

Chr 12: 83.79 – 83.92 Mb

PubMed search

ENSG00000133961

ENSMUSG00000021224

NM_001005743
NM_001005744
NM_001005745
NM_003744
NM_001320114

NM_001136075
NM_001272055
NM_001272056
NM_010949

NP_001005743
NP_001005744
NP_001005745
NP_001307043
NP_003735

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Wikipedia

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