NRXN3

Identifiers

NRXN3, C14orf60, neurexin 3

External IDs

Gene ontology
Molecular function	• neuroligin family protein binding • transmembrane signaling receptor activity • cell adhesion molecule binding • metal ion binding • receptor activity
Cellular component	• integral component of membrane • presynapse • membrane • plasma membrane • integral component of plasma membrane
Biological process	• chemical synaptic transmission • neuron cell-cell adhesion • social behavior • synapse assembly • positive regulation of synapse maturation • vocalization behavior • adult behavior • cell adhesion • learning • neurotransmitter secretion • angiogenesis • signal transduction • positive regulation of synapse assembly • axon guidance
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9369


n/a

Ensembl


ENSG00000021645


n/a

UniProt


Q9HDB5 Q9Y4C0


n/a

RefSeq (mRNA)


NM_001105250 NM_001272020 NM_004796 NM_138970 NM_001330195


n/a

RefSeq (protein)


NP_001098720.1 NP_001258949.1 NP_004787.2 NP_620426.2 NP_004787.2


n/a

Location (UCSC)

Chr 14: 78.17 – 79.87 Mb

n/a

PubMed search

n/a

9369

n/a

ENSG00000021645

n/a

Q9HDB5
Q9Y4C0

n/a

NM_001105250
NM_001272020
NM_004796
NM_138970
NM_001330195

n/a

NP_001098720.1
NP_001258949.1
NP_004787.2
NP_620426.2
NP_004787.2

n/a

Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 is thought to be involved in synaptic plasticity, and polymorphisms in NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction, or obesity.

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Wikipedia