NRXN2

NRXN2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4NXR
Identifiers
Aliases	NRXN2
External IDs	MGI: 1096362 HomoloGene: 86984 GeneCards: NRXN2
Gene ontology Molecular function • neuroligin family protein binding • transmembrane signaling receptor activity • metal ion binding • cell adhesion molecule binding • calcium channel regulator activity Cellular component • integral component of membrane • membrane • plasma membrane • protein complex • presynapse Biological process • neuron cell-cell adhesion • cell adhesion • signal transduction • chemical synaptic transmission • gephyrin clustering involved in postsynaptic density assembly • postsynaptic density protein 95 clustering • vocalization behavior • vocal learning • neuroligin clustering involved in postsynaptic membrane assembly • adult behavior • postsynaptic membrane assembly • social behavior • synapse assembly • neurotransmitter secretion • regulation of molecular function Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9379	18190
Ensembl	ENSG00000110076	n/a
UniProt	P58401 Q9P2S2	n/a
RefSeq (mRNA)	NM_015080 NM_138732 NM_138734	NM_001205234 NM_001205235 NM_020253
RefSeq (protein)	NP_620063.1 NP_055895.1 NP_620060.1	n/a
Location (UCSC)	Chr 11: 64.61 – 64.72 Mb	Chr 19: 6.42 – 6.54 Mb
PubMed search

4NXR

9379

18190

ENSG00000110076

n/a

P58401
Q9P2S2

n/a

NM_015080
NM_138732
NM_138734

NM_001205234
NM_001205235
NM_020253

NP_620063.1
NP_055895.1
NP_620060.1

n/a

Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.

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