NRCAM

NRCAM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UEN, 1UEY
Identifiers
Aliases	NRCAM, neuronal cell adhesion molecule
External IDs	MGI: 104750 HomoloGene: 21041 GeneCards: NRCAM
Gene ontology Molecular function • protein binding • protein binding involved in heterotypic cell-cell adhesion • ankyrin binding Cellular component • integral component of membrane • cell projection • membrane • plasma membrane • synapse • integral component of plasma membrane • extracellular region • axon • neuron projection • axon initial segment • external side of plasma membrane Biological process • protein localization • single organismal cell-cell adhesion • clustering of voltage-gated sodium channels • regulation of neuron projection development • regulation of axon extension • axonogenesis • heterotypic cell-cell adhesion • neuron migration • central nervous system development • cell adhesion • neuronal action potential propagation • angiogenesis • positive regulation of neuron differentiation • synapse assembly • axonal fasciculation • retinal ganglion cell axon guidance • axon guidance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4897	319504
Ensembl	ENSG00000091129	ENSMUSG00000020598
UniProt	Q92823	Q810U4
RefSeq (mRNA)	NM_001037132 NM_001037133 NM_001193582 NM_001193583 NM_001193584 NM_005010	NM_001146031 NM_176930
RefSeq (protein)	NP_001032209 NP_001180511 NP_001180512 NP_001180513 NP_005001	NP_001139503 NP_795904
Location (UCSC)	Chr 7: 108.15 – 108.46 Mb	Chr 12: 44.33 – 44.6 Mb
PubMed search

1UEN, 1UEY

4897

319504

ENSG00000091129

ENSMUSG00000020598

Q92823

Q810U4

NM_005010

NM_001146031
NM_176930

NP_001032209
NP_001180511
NP_001180512
NP_001180513
NP_005001

NP_001139503
NP_795904

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

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