NOX1

NOX1
Identifiers
Aliases	NOX1, GP91-2, MOX1, NOH-1, NOH1, NADPH oxidase 1
External IDs	MGI: 2450016 HomoloGene: 48495 GeneCards: NOX1
Gene ontology Molecular function • Rac GTPase binding • voltage-gated proton channel activity • superoxide-generating NADPH oxidase activity • metal ion binding • voltage-gated ion channel activity • protein binding • NADP binding • oxidoreductase activity Cellular component • cytoplasm • integral component of membrane • endosome • cell projection • membrane • invadopodium membrane • plasma membrane • cell junction • NADPH oxidase complex • early endosome Biological process • cellular stress response to acidic pH • NADP metabolic process • intracellular pH elevation • cellular response to hyperoxia • regulation of ion transmembrane transport • extracellular matrix organization • positive regulation of JNK cascade • oxygen metabolic process • ion transport • proton transport • positive regulation of integrin biosynthetic process • superoxide anion generation • regulation of blood pressure • respiratory burst • hydrogen peroxide metabolic process • angiogenesis • positive regulation of cell proliferation • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • positive regulation of vascular endothelial growth factor production • inflammatory response • regulation of systemic arterial blood pressure by renin-angiotensin • cell migration • oxidation-reduction process • signal transduction • superoxide metabolic process • positive regulation of smooth muscle cell proliferation • positive regulation of MAPK cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27035	237038
Ensembl	ENSG00000007952	ENSMUSG00000031257
UniProt	Q9Y5S8	Q8CIZ9
RefSeq (mRNA)	NM_013955 NM_001271815 NM_007052 NM_013954	NM_172203
RefSeq (protein)	NP_001258744 NP_008983 NP_039249	NP_757340.1 NP_757340
Location (UCSC)	Chr X: 100.84 – 100.87 Mb	Chr X: 134.09 – 134.22 Mb
PubMed search

27035

237038

ENSG00000007952

ENSMUSG00000031257

Q9Y5S8

Q8CIZ9

NM_013955
NM_001271815
NM_007052
NM_013954

NM_172203

NP_001258744
NP_008983
NP_039249

NP_757340.1
NP_757340

NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene.

NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene.

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Wikipedia