NOVA1

NOVA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DT4, 2ANN, 2ANR
Identifiers
Aliases	NOVA1, Nova-1, NOVA alternative splicing regulator 1
External IDs	MGI: 104297 HomoloGene: 21296 GeneCards: NOVA1
Gene ontology Molecular function • nucleic acid binding • mRNA binding • RNA binding Cellular component • nucleolus • intracellular membrane-bounded organelle • nucleus Biological process • mRNA splicing, via spliceosome • RNA processing • locomotory behavior • RNA splicing • regulation of RNA metabolic process • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4857	664883
Ensembl	ENSG00000139910	ENSMUSG00000021047
UniProt	P51513	Q9JKN6
RefSeq (mRNA)	NM_002515 NM_006489 NM_006491	NM_021361
RefSeq (protein)	NP_002506 NP_006480 NP_006482	NP_067336.1 NP_067336
Location (UCSC)	Chr 14: 26.44 – 26.6 Mb	Chr 12: 46.69 – 46.82 Mb
PubMed search

1DT4, 2ANN, 2ANR

4857

664883

ENSG00000139910

ENSMUSG00000021047

P51513

Q9JKN6

NM_002515
NM_006489
NM_006491

NM_021361

NP_002506
NP_006480
NP_006482

NP_067336.1
NP_067336

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.

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