NOD2

NOD2
Identifiers
Aliases	NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS
External IDs	MGI: 2429397 HomoloGene: 11156 GeneCards: NOD2
Gene ontology Molecular function • Hsp90 protein binding • nucleotide binding • Hsp70 protein binding • protein binding • peptidoglycan binding • enzyme binding • actin binding • CARD domain binding • ATP binding • protein kinase binding • muramyl dipeptide binding Cellular component • cytoplasm • cytosol • vesicle • membrane • plasma membrane • protein complex • cell surface • basolateral plasma membrane • COP9 signalosome • cytoskeleton • Golgi apparatus Biological process • positive regulation of prostaglandin-endoperoxide synthase activity • regulation of apoptotic process • defense response • detection of biotic stimulus • cytokine production involved in immune response • positive regulation of cytokine production involved in inflammatory response • intracellular signal transduction • detection of muramyl dipeptide • positive regulation of interleukin-10 production • positive regulation of epithelial cell proliferation • immune system process • positive regulation of oxidoreductase activity • response to muramyl dipeptide • positive regulation of prostaglandin-E synthase activity • positive regulation of JNK cascade • positive regulation of nitric-oxide synthase biosynthetic process • positive regulation of NIK/NF-kappaB signaling • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of gamma-delta T cell activation • cellular response to muramyl dipeptide • JNK cascade • negative regulation of macrophage apoptotic process • positive regulation of dendritic cell antigen processing and presentation • activation of MAPK activity • nucleotide-binding oligomerization domain containing 2 signaling pathway • maintenance of gastrointestinal epithelium • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • activation of MAPK activity involved in innate immune response • positive regulation of interleukin-8 production • positive regulation of interleukin-1 beta secretion • detection of bacterium • positive regulation of interleukin-1 beta production • regulation of inflammatory response • positive regulation of interleukin-6 production • protein oligomerization • positive regulation of tumor necrosis factor production • positive regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • cytokine secretion involved in immune response • positive regulation of B cell activation • positive regulation of interleukin-17 production • positive regulation of type 2 immune response • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of stress-activated MAPK cascade • positive regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter • cellular response to organic cyclic compound • positive regulation of cell proliferation • innate immune response • response to nutrient • positive regulation of dendritic cell cytokine production • protein deubiquitination • positive regulation of protein K63-linked ubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64127	257632
Ensembl	ENSG00000167207	ENSMUSG00000055994
UniProt	Q9HC29	Q8K3Z0
RefSeq (mRNA)	NM_001293557 NM_022162	NM_145857
RefSeq (protein)	NP_001280486 NP_071445	NP_665856
Location (UCSC)	Chr 16: 50.69 – 50.73 Mb	Chr 8: 88.65 – 88.69 Mb
PubMed search

64127

257632

ENSG00000167207

ENSMUSG00000055994

Q9HC29

Q8K3Z0

NM_001293557
NM_022162

NM_145857

NP_001280486
NP_071445

NP_665856

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1) is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.

NOD2 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.

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Wikipedia