NMNAT2

NMNAT2
Identifiers
Aliases	NMNAT2, C1orf15, PNAT2, nicotinamide nucleotide adenylyltransferase 2
External IDs	MGI: 2444155 HomoloGene: 75037 GeneCards: NMNAT2
Gene location (Human) Chr. Chromosome 1 (human) Band n/a Start 183,248,237 bp End 183,418,602 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band n/a Start 152,954,993 bp End 153,119,261 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • nucleotidyltransferase activity • catalytic activity • nicotinamide-nucleotide adenylyltransferase activity • ATP binding • nicotinate-nucleotide adenylyltransferase activity Cellular component • cytoplasm • Golgi membrane • late endosome • Golgi apparatus • trans-Golgi network • synapse Biological process • pyridine nucleotide biosynthetic process • NAD metabolic process • biosynthetic process • NAD biosynthetic process • 'de novo' NAD biosynthetic process from aspartate Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23057	226518
Ensembl	ENSG00000157064	ENSMUSG00000042751
UniProt	Q9BZQ4	Q8BNJ3
RefSeq (mRNA)	NM_170706 NM_015039	NM_175460
RefSeq (protein)	NP_055854 NP_733820	NP_780669
Location (UCSC)	Chr 1: 183.25 – 183.42 Mb	Chr 1: 152.95 – 153.12 Mb
PubMed search

23057

226518

ENSG00000157064

ENSMUSG00000042751

Q9BZQ4

Q8BNJ3

NM_170706
NM_015039

NM_175460

NP_055854
NP_733820

NP_780669

Nicotinamide mononucleotide adenylyltransferase 2 is an enzyme that in humans is encoded by the NMNAT2 gene.

This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in the nicotinamide adenine dinucleotide (NAD (NADP)) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.

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