NLGN4X

NLGN4X
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2WQZ, 2XB6, 3BE8
Identifiers
Aliases	NLGN4X, ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4, neuroligin 4, X-linked
External IDs	HomoloGene: 136297 GeneCards: NLGN4X
Gene ontology Molecular function • protein homodimerization activity • scaffold protein binding • carboxylic ester hydrolase activity • neurexin family protein binding • protein binding • chloride ion binding • cell adhesion molecule binding • receptor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • postsynaptic density of dendrite • synapse • integral component of plasma membrane • excitatory synapse • cell surface • cell junction • dendrite • plasma membrane • intracellular Biological process • cell-cell junction organization • organ growth • neuron cell-cell adhesion • brainstem development • synapse organization • learning • cerebellum development • negative regulation of excitatory postsynaptic potential • presynaptic membrane assembly • vocalization behavior • adult behavior • cell adhesion • neuron differentiation • social behavior • synaptic vesicle endocytosis • postsynaptic membrane assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57502	n/a
Ensembl	ENSG00000146938	n/a
UniProt	Q8N0W4	n/a
RefSeq (mRNA)	NM_001282145 NM_001282146 NM_020742 NM_181332	n/a
RefSeq (protein)	NP_001269074 NP_001269075 NP_065793 NP_851849	n/a
Location (UCSC)	Chr X: 5.84 – 6.23 Mb	n/a
PubMed search		n/a

2WQZ, 2XB6, 3BE8

57502

n/a

ENSG00000146938

n/a

Q8N0W4

n/a

NM_001282145
NM_001282146
NM_020742
NM_181332

n/a

NP_001269074
NP_001269075
NP_065793
NP_851849

n/a

Neuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.

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