NLGN3

NLGN3
Identifiers
Aliases	NLGN3, HNL3, neuroligin 3
External IDs	MGI: 2444609 HomoloGene: 23133 GeneCards: NLGN3
Gene location (Human) Chr. X chromosome (human) Band No data available Start 71,144,831 bp End 71,171,201 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band No data available Start 101,299,168 bp End 101,325,963 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • scaffold protein binding • neurexin family protein binding • carboxylic ester hydrolase activity • cell adhesion molecule binding • protein binding • receptor activity Cellular component • integral component of membrane • membrane • cell surface • synapse • cell junction • endocytic vesicle • excitatory synapse • plasma membrane • integral component of plasma membrane • integral component of postsynaptic membrane Biological process • regulation of AMPA receptor activity • positive regulation of synaptic vesicle clustering • social behavior • rhythmic synaptic transmission • regulation of NMDA receptor activity • regulation of synaptic transmission, glutamatergic • excitatory postsynaptic potential • positive regulation of AMPA receptor activity • synapse organization • negative regulation of excitatory postsynaptic potential • modulation of chemical synaptic transmission • regulation of respiratory gaseous exchange by neurological system process • axon extension • learning • long-term synaptic potentiation • vocalization behavior • negative regulation of dendritic spine morphogenesis • neuron cell-cell adhesion • regulation of dendritic spine morphogenesis • receptor-mediated endocytosis • cell adhesion • oligodendrocyte differentiation • regulation of terminal button organization • adult behavior • positive regulation of excitatory postsynaptic potential • positive regulation of synaptic transmission, glutamatergic • regulation of long-term synaptic potentiation • visual learning • inhibitory postsynaptic potential • positive regulation of synapse assembly • synapse assembly • synaptic vesicle endocytosis • postsynaptic membrane assembly • presynaptic membrane assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54413	245537
Ensembl	ENSG00000196338	ENSMUSG00000031302
UniProt	Q9NZ94	Q8BYM5
RefSeq (mRNA)	NM_001166660 NM_018977 NM_181303 NM_001321276	NM_172932
RefSeq (protein)	NP_001160132 NP_001308205 NP_061850 NP_851820 NP_001160132.1	NP_766520
Location (UCSC)	Chr X: 71.14 – 71.17 Mb	Chr X: 101.3 – 101.33 Mb
PubMed search

54413

245537

ENSG00000196338

ENSMUSG00000031302

Q9NZ94

Q8BYM5

NM_001166660
NM_018977
NM_181303
NM_001321276

NM_172932

NP_001160132
NP_001308205
NP_061850
NP_851820
NP_001160132.1

NP_766520

Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene.

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with Autism Spectrum Disorders (ASDs). Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.

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