NHERF1

SLC9A3R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G9O, 1GQ4, 1GQ5, 1I92, 2D10, 2JXO, 2KJD, 2KRG, 2M0T, 2M0U, 2M0V, 2OZF, 4JL7, 4LMM, 4MPA, 4N6X, 4PQW, 4Q3H
Identifiers
Aliases	SLC9A3R1, EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2, Sodium-hydrogen antiporter 3 regulator 1, SLC9A3 regulator 1
External IDs	MGI: 1349482 HomoloGene: 3137 GeneCards: SLC9A3R1
Gene ontology Molecular function • protein self-association • growth factor receptor binding • dopamine receptor binding • beta-catenin binding • beta-2 adrenergic receptor binding • phosphatase binding • receptor binding • protein complex scaffold • protein binding • protein complex binding • protein domain specific binding • chloride channel regulator activity • PDZ domain binding Cellular component • brush border membrane • vesicle • endomembrane system • nucleus • cell periphery • cell projection • actin cytoskeleton • perinuclear region of cytoplasm • apical part of cell • ruffle • stereocilium • extracellular exosome • membrane • membrane raft • microvillus membrane • cytoplasm • microvillus • stereocilium tip • apical plasma membrane • sperm midpiece • filopodium • plasma membrane • intracellular membrane-bounded organelle Biological process • negative regulation of cell proliferation • establishment of protein localization to plasma membrane • regulation of protein kinase activity • positive regulation of intrinsic apoptotic signaling pathway • regulation of cell size • actin cytoskeleton organization • renal absorption • regulation of sodium:proton antiporter activity • phospholipase C-activating dopamine receptor signaling pathway • microvillus assembly • establishment of nucleus localization • bile acid secretion • cAMP-mediated signaling • establishment of Golgi localization • sensory perception of sound • renal phosphate ion absorption • cellular protein localization • gland morphogenesis • negative regulation of cell motility • negative regulation of protein kinase B signaling • auditory receptor cell stereocilium organization • negative regulation of phosphatidylinositol 3-kinase signaling • establishment of epithelial cell apical/basal polarity • negative regulation of ERK1 and ERK2 cascade • adenylate cyclase-activating dopamine receptor signaling pathway • regulation of excretion • cellular phosphate ion homeostasis • negative regulation of mitotic cell cycle • glutathione transport • renal sodium ion transport • negative regulation of sodium:proton antiporter activity • negative regulation of platelet-derived growth factor receptor signaling pathway • negative regulation of cell migration • negative regulation of catenin import into nucleus • regulation of cell shape • Wnt signaling pathway • negative regulation of sodium ion transport • protein complex assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9368	26941
Ensembl	ENSG00000109062	ENSMUSG00000020733
UniProt	O14745	P70441
RefSeq (mRNA)	NM_004252	NM_012030
RefSeq (protein)	NP_004243	NP_036160.1 NP_036160
Location (UCSC)	Chr 17: 74.75 – 74.77 Mb	Chr 11: 115.16 – 115.18 Mb
PubMed search

1G9O, 1GQ4, 1GQ5, 1I92, 2D10, 2JXO, 2KJD, 2KRG, 2M0T, 2M0U, 2M0V, 2OZF, 4JL7, 4LMM, 4MPA, 4N6X, 4PQW, 4Q3H

9368

26941

ENSG00000109062

ENSMUSG00000020733

O14745

P70441

...
Wikipedia